Variance stabilizing the risk difference to obtain confidence intervals for effects and effec

Host Institution:

La Trobe University, AGR Room.

Title of Seminar:

Variance stabilizing the risk difference to obtain confidence intervals for effects and effec

Speaker's Name:

Associate Professor, Dr Robert Staudte

Speaker's Institution:

La Trobe University

Time and Date:

2:00pm Friday 16 May 2008

Seminar Abstract:

The usual estimator of the risk difference is variance stabilized, conditionally on an estimated weighted average of the unknown risks. This leads to conditional confidence intervals for the standardized risk difference, and hence for a correlation effect size. In addition, it leads to confidence intervals for the risk difference itself, with more accurate unconditional coverage than those obtained by standard asymptotic methods, as shown by simulations studies. Methods for combining the results of several studies are presented, and illustrated on nine independent randomized clinical trials of the effect of diuretics on pre-eclampsia.

Seminar Convenor:

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AGR IT support:

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