Development of optimal designs for population pharmacokinetic studies of artesunate

 

Host Institution:

La Trobe University

Title of Seminar:

Development of optimal designs for population pharmacokinetic studies of artesunate

Speaker's Name:

Kris Jamsen

Speaker's Institution:

The University of Melbourne

Time and Date:

Friday 20 November 2009 at 11:00 am

Seminar Abstract:

Effective treatment of malaria requires that the dose and frequency of administration of the antimalarial drug provide drug concentrations over time (known as the 'pharmacokinetic profile') sufficient to kill all of the parasites in the body.  Population pharmacokinetic (PK) studies determine the PK profiles in the patient populations by using complex statistical models that allow sparse data from patients where intensive blood sampling is not feasible. Currently, population PK studies of antimalarial drugs are designed without formally considering the statistical models that are fitted to the data, which could lead to designs where it is impossible to estimate the target PK parameters, wasting time and money.

We have developed and evaluated designs for future population PK studies of artesunate using optimal design theory [1], which analytically determines a design (i.e. a set of blood sampling times) that maximizes the precision of the PK parameters considering the practical constraints of sampling the patients.  The designs include the high risk groups, pregnant women and children, for whom there is

very little PK data available.

1. Retout S, Duffull S, Mentre F. Development and implementation of the population Fisher information matrix for the evaluation of population pharmacokinetic designs. Comput Methods Programs Biomed 65(2): 141-151, 2001.

Seminar Convenor:

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AGR IT support:

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